Iron dysregulation and mitochondrial dysfunction in aging: A longitudinal study on mobility decline in low- and high-functioning older adults
This study is among the first to investigate how biomarkers of iron dysregulation, mitochondrial function, and related ferroptosis and senescence pathways may contribute to changes in physical function in LF and HF older adults. By integrating molecular and functional assessments, the study will inform how disrupted iron handling and mitochondrial health influence mobility trajectories in aging populations.
Authors
- Christian McLaren (ORCID: https://orcid.org/0000-0001-5997-3868)
- Rola S Zeidan (ORCID: https://orcid.org/0009-0000-0838-0122)
- Robert T. Mankowski (ORCID: https://orcid.org/0000-0002-8617-9931)
- Kevin G. Wu (ORCID: https://orcid.org/0000-0002-3391-0815)
- Nevena Stanojevic
- S. Wohlgemuth
- Javier Tamargo (ORCID: https://orcid.org/0000-0001-9385-9049)
- Anna Picca
- Aditya S. Shirali
- Xiangyang Lou
- Todd Manini
- Bhanuprasad Sandesara
- Bella Bravo
- Emanuele Marzetti
- Christiaan Leeuwenburgh
- Stephen Anton
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Florida Health (US)
- Agostino Gemelli University Polyclinic (IT)
- Moffitt Cancer Center (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.exger.2026.113062
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00