Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes
P2RX7 is most consistently and specifically associated with bipolar disorder, schizophrenia, and major depression, supported by both statistical and biological evidence.
Authors
- Qiao Mao
- Xiaoyun Guo
- Zhiren Wang
- Jiawu Ji
- Lingjun Zuo
- Fude Yang
- Xiaowei Lu
- Jennifer Luo
- YONG ZHANG
- Jianming Zheng
- Xiaoping Wang
- Xingguang Luo
- Ling Zhu
- Ping Liu
- Na Liu
- Zhixiong Luo
- Bin Chen
- Fan WANG
- Jia Hu
Institutions
- Macau University of Science and Technology (MO)
- Fujian University of Traditional Chinese Medicine (CN)
- Tufts University (US)
- Fujian Medical University (CN)
- Central South University (CN)
- University of South Carolina (US)
- Peking University (CN)
- University of Macau (MO)
- Renji Hospital (CN)
- XinHua Hospital (CN)
- Shanghai Mental Health Center (CN)
- Yale University (US)
- Tianjin Anding Hospital (CN)
- Neurobehavioral Systems (US)
- 174th hospital of the People's Liberation Army (CN)
- Nanjing Brain Hospital (CN)
- Deyang Stomatological Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Beijing HuiLongGuan Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Huashan Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.jad.2026.121327
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00