A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Layered double hydroxide (LDH)-based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT-mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5-iodoisophthalic acid (I-IPA)-intercalated MgZnAl-LDH onto bioactive glass scaffold (BGS) to construct a bifunctional composite scaffold (BGS/I-LDH) for integrated osteosarcoma treatment and bone regeneration. The surface functionalization of I-LDH onto BGS confers BGS/I-LDH high-efficiency reactive oxygen species generation performance under 1270 nm laser irradiation, resulting in a singlet oxygen quantum yield up to 1.53, which is significantly superior to that of previously reported NIR-excited PSs. Moreover, thanks to the sustained release of Mg²⁺ and Zn²⁺ ions from I-LDH, BGS/I-LDH exhibits exceptional anti-osteosarcoma and osteogenic properties with 3.8-fold bone volume, 3.0-fold bone mineral density, and 11.4-fold new bone mass increments compared with the pristine BGS, which is remarkably more preponderant than other previously reported modified BGS.