Electron-Shuttle Catalysis by Diaryl Diselenides for Photochemical Anti-Markovnikov Hydroalkoxylation of Alkenes
The development of general anti-Markovnikov hydroalkoxylation methods remains challenging due to competing alkene oxidation and photocatalyst-alcohol compatibility issues. Herein, diaryl diselenides serve as efficient electron-shuttle catalysts for visible-light-driven anti-Markovnikov hydroalkoxylation in combination with TPT<sup>+</sup>BF<sub>4</sub><sup>-</sup>. A broad range of aryl- and alkyl-substituted alkenes and diverse alcohols are accommodated, affording products up to 97% yield. Mechanistic studies reveal a diselenide-mediated, multistep electron-shuttle pathway that enables mild and selective transformations.
Authors
- Hun Young Kim (ORCID: https://orcid.org/0000-0002-8461-8910)
- InHo Jang
- Kyungsoo Oh (ORCID: https://orcid.org/0000-0002-4566-6573)
Institutions
- Chung-Ang University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1021/acs.orglett.6c00049
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00