CLK1 is a potential tumor suppressor for NSCLC by regulating cell proliferation and immune infiltration
Our findings demonstrate that CLK1 functions as a tumor suppressor gene in NSCLC, inhibiting proliferation and promoting immune infiltration. It also correlates positively with sensitivity to multiple chemotherapeutic agents. Thus, CLK1 may serve as a novel prognostic biomarker and a potential target for combination therapy in NSCLC.
Authors
- Yunlong Wang (ORCID: https://orcid.org/0000-0002-3535-308X)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Rui Ma
- Jia Ma
Institutions
- Huazhong Agricultural University (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fcell.2026.1758135
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hubei University