The effect of levodopa on speech graphs in non-demented patients with multiple system atrophy and Parkinson’s disease
MSA-P patients' speech graphs were denser and smaller than both PD patients and healthy adults. The graph analysis of semantic fluency can differentiate MSA-P from PD to some extent. Importantly, in MSA-P patients, the impaired speech topology can be partially restored by levodopa.
Authors
- Jingyue Liu (ORCID: https://orcid.org/0000-0002-2267-1433)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-5866-5932)
- Guanyu Zhang (ORCID: https://orcid.org/0000-0003-0965-218X)
- Jinghong Ma
Institutions
- Capital Medical University (CN)
- Fourth People’s Hospital of Jinan (CN)
- National Clinical Research (US)
- China Institute of Sport Science (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fneur.2026.1746101
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00