Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment
Digestive diseases comprise a diverse range of illnesses, which are prevalent worldwide and represent an important health issue. This is particularly relevant for the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its close association with the obesity pandemic, contributing to the escalation of MASLD as the most common form of chronic liver disease, and the main cause of liver cancer. Not only does MASLD reflect the deterioration of liver health, but it also has far-reaching consequences for the development of extrahepatic digestive diseases. Along with the progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammation in diseases of the digestive tract, drug-induced liver injury, and cholestasis, drives and contributes to the rise of these diseases in the future, which merit the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management, and treatment. With this goal in mind, the current collaborative review gathers experts in a wide range of liver and digestive diseases to provide an up-to-date overview of the mechanisms of disease and identify novel strategies for the improvement of these important health issues.
Authors
- Jianguo Chen (ORCID: https://orcid.org/0000-0003-4102-8934)
- Honoré Zougmoré
- O. Tirosh
- Camélia Mokhtari
- José C. Fernández‐Checa (ORCID: https://orcid.org/0000-0003-3422-2990)
- C. Raggi
- Ina Bergheim (ORCID: https://orcid.org/0000-0002-3356-4115)
- Robert Eferl (ORCID: https://orcid.org/0000-0002-6074-7144)
- Firouzeh Kazerouni
- Pavel Strnad
- Amedeo Lonardo (ORCID: https://orcid.org/0000-0001-9886-0698)
- Han Moshage
- Cadranel Jf
- DA Mann
- Wenxing Ding
- Nahum Méndez-Sánchez
- Hartmut Jaeschke
Institutions
- University of Vienna (AT)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Hebrew University of Jerusalem (IL)
- Comprehensive Cancer Center Vienna (AT)
- Hospital Médica Sur (MX)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Universitätsklinikum Aachen (DE)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- University of Kansas Medical Center (US)
- Qidong Liver Cancer Prevention Research (CN)
- Centre Hospitalier Laennec (FR)
- University of Florence (IT)
- Medical University of Vienna (AT)
- Newcastle University (GB)
- FH Aachen (DE)
Publication Details
- Journal
- Exploration of Digestive Diseases
- Published
- 2026-02-09
- DOI
- https://doi.org/10.37349/edd.2026.1005110
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Associazione Italiana per la Ricerca sul Cancro
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- National Institutes of Health
- Plan Nacional sobre Drogas
- European Regional Development Fund
- Agencia Estatal de Investigación
- National Cancer Institute