Severe malaria treatment with rectal artesunate and artemisinin-based combination therapy in remote settings: an effectiveness-implementation hybrid type 3 study protocol (SEMA ReACT)
This study will provide essential evidence on the feasibility and effectiveness of community-based pre-referral treatment for severe malaria in resource-limited settings, address access barriers to injectable artesunate and facility-based care, inform policy and programmatic adaptations and guide scalable strategies to enhance timely treatment, reduce mortality and mitigate drug resistance in high-burden malaria regions.
Authors
- Shepherd Khondowe (ORCID: https://orcid.org/0000-0002-6882-2065)
- Aimé Kakudji
- Vito Baraka (ORCID: https://orcid.org/0000-0001-9694-9293)
- Michael Nambozi (ORCID: https://orcid.org/0000-0002-0369-0970)
- Ghislain Kikunda
- Donald Mukumbuta
- Éric Mukomena Sompwe
- Christine Manyando (ORCID: https://orcid.org/0000-0002-5535-0599)
- Busiku Hamainza (ORCID: https://orcid.org/0000-0001-7204-1555)
- Hans Rietveld
- Geofrey Makenga (ORCID: https://orcid.org/0000-0001-5681-9785)
- Hypolite Muhindo Mavoko (ORCID: https://orcid.org/0000-0002-3307-3324)
- Flory Luzolo Khote
- Augustin Mutombo
- Tafadzwa Maseko
- Stephan Duparc
- Deborah Kanyamukenge
- Sebastian Hachizovu
Institutions
- Ministry of Public Health (CD)
- Ministry of Health (ZM)
- University of Lubumbashi (CD)
- University of Antwerp (BE)
- University of Kinshasa (CD)
- Université Protestante de Lubumbashi (CD)
- Institut Supérieur de Statistique de Lubumbashi (CD)
- National Institute of Public Administration (ZM)
- National Institute for Medical Research (TZ)
- Medicines for Malaria Venture (CH)
Publication Details
- Journal
- Malaria Journal
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s12936-026-05816-0
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 41.85