Time to Cross Paths: Neuroplasticity-Informed ACL Rehabilitation that Includes Cross-Education

The efficacy of anterior cruciate ligament (ACL) rehabilitation following reconstruction surgery is sub-optimal and the return-to-sport criteria are inconsistent. We examine the hypothesis that the dysfunctional neuroplasticity induced by an ACL injury could be resolved faster when cross-education is combined with innovative paradigms incorporating visual-cognitive tasks to reduce attentional compensation. We posit that the priming effects could be amplified if therapists combined higher force, eccentric based cross-education exercises with visual-cognitive dual-tasking. The overlapping nature of neuroplasticity after an ACL injury and that induced by cross education may provide a pathway to not only address the mechanical muscle strength deficits associated with injury, but the underlying neurological deficits as well. We provide a practical guide to how neuroplasticity-informed ACL rehabilitation that includes cross-education might accelerate recovery from an ACL injury and the subsequent reconstruction surgery.

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Publication Details

Journal
Sports Medicine - Open
Published
2026-02-09
DOI
https://doi.org/10.1186/s40798-025-00967-x
Primary Topic
Knee injuries and reconstruction techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Time to Cross Paths: Neuroplasticity-Informed ACL Rehabilitation that Includes Cross-Education

Justin W. Andrushko, Márk Váczi, Jonathan P. Farthing, Tibor Mintál et al.
Sports Medicine - Open
Knee injuries and reconstruction techniques
article

Time to Cross Paths: Neuroplasticity-Informed ACL Rehabilitation that Includes Cross-Education

Justin W. Andrushko, Márk Váczi, Jonathan P. Farthing, Tibor Mintál, Dustin R. Grooms, Nicola A. Maffiuletti, Leila Bogdán, Gergely Orsi, Tibor Hortobágyi, Rubén Lara Gómez
article en

Abstract

The efficacy of anterior cruciate ligament (ACL) rehabilitation following reconstruction surgery is sub-optimal and the return-to-sport criteria are inconsistent. We examine the hypothesis that the dysfunctional neuroplasticity induced by an ACL injury could be resolved faster when cross-education is combined with innovative paradigms incorporating visual-cognitive tasks to reduce attentional compensation. We posit that the priming effects could be amplified if therapists combined higher force, eccentric based cross-education exercises with visual-cognitive dual-tasking. The overlapping nature of neuroplasticity after an ACL injury and that induced by cross education may provide a pathway to not only address the mechanical muscle strength deficits associated with injury, but the underlying neurological deficits as well. We provide a practical guide to how neuroplasticity-informed ACL rehabilitation that includes cross-education might accelerate recovery from an ACL injury and the subsequent reconstruction surgery.

Sports Medicine - OpenVol. 12(1)
University Medical Center Groningen (NL), Northumbria University (GB), University of Saskatchewan (CA), Ohio University (US), Schulthess-Klinik (CH), Hungarian School Sport Federation (HU), Andalusian Centre for Nanomedicine and Biotechnology (ES), Instituto de Investigación Biomédica de Málaga (ES), University of Pecs (HU), Universidad de Málaga (ES)
Hungarian Scientific Research Fund, National Research, Development and Innovation Office
Quality Education
Openalex Percentile: Top 62%
Knee injuries and reconstruction techniques
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