Enhancing NK Cell Activity in Colorectal Cancer with an Fc-Optimized Antibody Targeting CD276 (B7-H3)
The Fc-optimized anti-CD276 antibody 8H8_SDIE effectively enhanced NK cell reactivity against CD276-positive CRC cells and induced tumor cell lysis in vitro. These findings suggest that 8H8_SDIE holds potential as a novel immunotherapeutic candidate for CRC, particularly for patients with microsatellite-stable disease, and warrants further evaluation in advanced preclinical and future clinical studies.
Authors
- Ilona Hagelstein
- Samuel J. Holzmayer (ORCID: https://orcid.org/0009-0006-4513-2367)
- Martina S. Lutz (ORCID: https://orcid.org/0000-0003-2576-2442)
- Sylwia A. Stefańczyk (ORCID: https://orcid.org/0000-0002-4134-4171)
- Latifa Zekri (ORCID: https://orcid.org/0000-0002-9844-7948)
- Xenija Kaiser
- Susanne Jung
- Melanie Märklin
Institutions
- Research Institute for Work, Technology and Culture (DE)
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/itt.s533342
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Eberhard Karls Universität Tübingen
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe