Oral ferrous sulphate supplementation has greater efficacy, but lower tolerance than iron (III)-hydroxide polymaltose complexes in exercising women with low iron stores
FS was superior in repleting ferritin concentrations after 12 weeks compared with IPC; however, FS also resulted in a greater number and severity of GI symptoms than IPC. Our data shows FS is the superior iron formulation for ID treatment, however future research should continue to address how to improve FS tolerance.. This trial was registered at https://www.anzctr.org.au/Trial/Registration/TrialReview as ACTRN12623000529640.
Authors
- Alannah K. A. McKay (ORCID: https://orcid.org/0000-0002-4184-3886)
- Sophie C. Broome (ORCID: https://orcid.org/0000-0002-4163-7847)
- Peter Peeling (ORCID: https://orcid.org/0000-0002-3895-0015)
- Nicolin Tee (ORCID: https://orcid.org/0000-0003-1130-9516)
- Louise M. Burke
- Marc Sim
- Kin Lui Yim
Institutions
- Edith Cowan University (AU)
- The University of Western Australia (AU)
- Western Australian Marine Science Institution (AU)
- Australian Catholic University (AU)
Publication Details
- Journal
- Clinical Nutrition
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.clnu.2026.106594
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00