Serum-urine metabolic integration via UPLC-QTOF/MS uncovers shared pathway biomarkers for cirrhosis diagnosis
This study delineates the distinct metabolic signatures of cirrhosis and proposes a diagnostic strategy based on dual - biofluid analysis. The intersectional biomarkers and pathways elucidate the mechanisms linking bile acid homeostasis and hemoprotein catabolism to cirrhotic progression, offering a noninvasive approach for clinical detection.
Authors
- Hongbing Zhou (ORCID: https://orcid.org/0000-0003-4591-0625)
- Runxi Wang
- Ruixue Li
- Hong Chang
- Xiaogang Li
- Songli Shi
Institutions
- Inner Mongolia University of Science and Technology (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fmed.2025.1646323
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia
- Baotou Medical College