GRAD: A Two-Stage Algorithm for Resolving Diagnostic Uncertainty in the Plasma p-tau217 Gray Zone

Our clinically-staged diagnostic algorithm, 'GRAD', provides actionable classifications for the majority of patients while routing uncertain cases for additional workup. The GRAD framework offers a practical, cost-effective approach for implementing plasma biomarkers in clinical practice. Future iterations of this framework, with integration of novel biomarkers like MTBR-tau243 present a significant opportunity to alleviate the AD health-economic burden and eliminate expensive but unnecessary diagnostic measures.