Pharmacomultiomics suggests new off-targets for targeted anti-cancer agents
• Multi-omics of 900+ cell lines links drug sensitivity to 6 omics layers • EGFR-TKIs show novel epigenetic and metabolic off-target effects • Butyrylcarnitine serves as a potential biomarker for ibrutinib sensitivity • KPT-9274 disrupts CoA metabolism in addition to NAMPT/PAK4 inhibition • NAMPT upregulation contributes to KPT-9274 resistance
Authors
- Eunbyul Cho (ORCID: https://orcid.org/0000-0002-1540-6447)
- Hyuk Nam Kwon (ORCID: https://orcid.org/0000-0003-4096-4712)
- Xuan Linh
- Sunghyouk Park
- Chae-Young Lee
Institutions
- Seoul National University (KR)
- University of Ulsan (KR)
- Ulsan University Hospital (KR)
Publication Details
- Journal
- Journal of Pharmaceutical Analysis
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jpha.2026.101580
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00