Evaluation of the antioxidant and anti-inflammatory efficacy of fermented Polygonatum sibiricum using zebrafish model

FPS treatment dose-dependently ameliorated UV-induced fin shrinkage and significantly reduced ROS accumulation. At 0.20 mg/mL, FPS markedly elevated SOD and CAT activities while decreasing MDA levels (<i>p</i> < 0.01). It also reduced UV-triggered skin cell apoptosis and modulated key inflammatory genes. In the SLS model, FPS significantly suppressed neutrophil migration (<i>p</i> < 0.05). <b>Conclusions</b>: FPS demonstrated significant protective effects against skin damage by alleviating oxidative stress, reducing apoptosis, and suppressing inflammation in zebrafish, supporting its potential as a natural ingredient for cosmetic applications.