Disruption of cellular calcium homeostasis by duck Tembusu virus facilitates viral replication via AMPK pathway activation
DTMUV disrupts host Ca²<sup>+</sup> homeostasis to activate AMPK, which promotes viral RNA replication. This study provides novel insights into DTMUV pathogenesis and identifies Ca²<sup>+</sup>-AMPK signaling as a potential anti-DTMUV target.
Authors
- Zejun Xu
- Wenxiao Zhuo (ORCID: https://orcid.org/0009-0008-3574-9018)
- Ziding Yu (ORCID: https://orcid.org/0000-0002-2932-8734)
- Guangshuang Zhu
- H. Y. Zhang
- Julong Wang
- Ran Xiong
- Chao Li
- Jingliang Su
- Benzhong Wang
- Ting Li
- Kuanhui Liu
- Zhenxing Ma
Institutions
- Zhejiang Normal University (CN)
- Technical and Vocational University (IR)
- Detection Limit (United States) (US)
- China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fcimb.2026.1743907
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China