In vivo evaluation of a cytochrome P450 gene from poultry red mite, Dermanyssus gallinae, as a vaccine antigen for chicks
Our findings demonstrated that the Deg-CYP-3 gene exhibits high transcriptional activity during both the adult and nymph stages of D. gallinae. Moreover, its expression remains consistent regardless of the feeding status of adult mites. Immunization with rCYP-3 effectively reduced mite survival, reproductive capacity, and gene expression levels, demonstrating its potential as a preventive and control strategy against D. gallinae.
Authors
- Yuzhu Zuo (ORCID: https://orcid.org/0000-0002-8846-3231)
- Chuanwen Wang (ORCID: https://orcid.org/0009-0007-1970-3274)
- Meng Wu (ORCID: https://orcid.org/0009-0007-3232-6696)
- Junlong Liu (ORCID: https://orcid.org/0000-0003-3863-9152)
- Zhonghao Wang
- Jianhua Qin
- Yicun Guo
- Jing Liu
- Shuo Yin
- Jianhua Zhang
- Zhengjie Wang
Institutions
- Hebei Agricultural University (CN)
- Shijiazhuang University (CN)
- Shijiazhuang Yiling Pharmaceutical (China) (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13071-025-07218-8
- Primary Topic
- Bird parasitology and diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00