Personalized Combination Therapy in Bladder Cancer: cAMP Modulators Synergize with 5-FU and Modulate Redox Programs

cAMP modulators selectively potentiate 5-FU in bladder cancer cells and modulate redox programs (notably with terbutaline), supporting a biomarker-guided combination strategy (e.g., β2-AR/PDE3/PI3K-Akt features) for personalized therapy in bladder cancer; mechanistic and in vivo validation are warranted.

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Publication Details

Journal
Cancers
Published
2026-02-09
DOI
https://doi.org/10.3390/cancers18040562
Primary Topic
Phosphodiesterase function and regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Personalized Combination Therapy in Bladder Cancer: cAMP Modulators Synergize with 5-FU and Modulate Redox Programs

Eduarda Ribeiro, Nuno Vale
Cancers
Phosphodiesterase function and regulation
article

Personalized Combination Therapy in Bladder Cancer: cAMP Modulators Synergize with 5-FU and Modulate Redox Programs

Eduarda Ribeiro, Nuno Vale
article en

Abstract

cAMP modulators selectively potentiate 5-FU in bladder cancer cells and modulate redox programs (notably with terbutaline), supporting a biomarker-guided combination strategy (e.g., β2-AR/PDE3/PI3K-Akt features) for personalized therapy in bladder cancer; mechanistic and in vivo validation are warranted.

CancersVol. 18(4)
Universidade do Porto (PT)
Openalex Percentile: Top 62%
Phosphodiesterase function and regulation
DOIOpen Access PDFOpenAlex
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Personalized Combination Therapy in Bladder Cancer: cAMP Modulators Synergize with 5-FU and Modulate Redox Programs — Eduarda Ribeiro, Nuno Vale · Cancers (2026) | TGRS Research Map | TGRS