NMR metabolomic profiling of cerebrospinal fluid from dogs with meningoencephalitis of unknown origin demonstrates metabolic similarities to multiple sclerosis

These results suggest that there is an increased energy demand in MUO. Our findings provide a first-time overview of CSF metabolic changes in MUO and offer potential insights for possible underlying pathogenesis and treatment strategies. Altered energy metabolism pathways are also reported in MS, further supporting the use of MUO as a spontaneous animal model for this disease.