Natural Killer Cell Dysregulation During ALS Disease Progression
NK cells grow more dysregulated with ALS progression, shifting from a classical Type 1 phenotype to a Type 2 phenotype, though a larger study will be needed to confirm these initial findings. The findings also suggest NK cells contribute to early, but not late, ALS progression. Targeting specific NK cell pathways during early ALS may be a viable therapeutic strategy.
Authors
- Joshua P. Famie
- Caroline E. Piecuch
- Benjamin J. Murdock (ORCID: https://orcid.org/0000-0002-3543-4007)
- Samuel J. Teener (ORCID: https://orcid.org/0009-0003-9072-8184)
- Stephen A. Goutman (ORCID: https://orcid.org/0000-0001-8780-6637)
- Kai Guo (ORCID: https://orcid.org/0009-0002-5171-3812)
- Dae-Gyu Jang
- Jihyun Park
- Junguk Hur
- Ian F. Webber-Davis
Institutions
- University of North Dakota (US)
- University of Michigan (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1212/wn9.0000000000000067
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00