Crocin protects against smoke-induced chronic obstructive pulmonary disease by regulating AKT1
These findings support the therapeutic potential of crocin in COPD through its anti-inflammatory activity and regulation of AKT1. Despite potential PAINS properties, the consistency across network, <i>in vitro</i>, and <i>in vivo</i> data strengthens the biological relevance of its observed effects.
Authors
- Yuehong Zhu (ORCID: https://orcid.org/0000-0002-0971-5577)
- YunTao Jiang
- Jieping Xu
- Zhihong Ma
- Sicheng Yan
Institutions
- Zhejiang Chinese Medical University (CN)
- Harbin Medical University (CN)
- Huzhou Normal University (CN)
- Wuqing District People's Hospital (CN)
- Daqing City People's Hospital (CN)
- Huzhou Central Hospital (CN)
- People’s Hospital of Linqing (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fphar.2026.1687752
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Huzhou Municipal Science and Technology Bureau