MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming
Our data demonstrate that the enhanced MTFP1 expression leads to an upregulated glutamine-OXPHOS axis in PDAC liver colonisation. This metabolic shift is triggered by the ROS/PI3K/AKT/c-MYC/SLC1A5 pathway. Targeting MTFP1 may be a potential therapeutic strategy for PDAC patients with liver metastasis.
Authors
- Yi-Ze Zhang
- Chunyang Mu (ORCID: https://orcid.org/0000-0001-6765-6897)
- Ziyang Wei (ORCID: https://orcid.org/0000-0002-4286-8946)
- H. Henry Guo (ORCID: https://orcid.org/0000-0001-5511-1750)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-2179-3698)
- Ting Liang (ORCID: https://orcid.org/0000-0003-3783-4191)
- Yu Dong (ORCID: https://orcid.org/0000-0002-0231-6274)
- Yiting Xu
- Wanyue Cao
- Yu-Xiong Feng
- Xiao-Bao Wei
- Gao-Wei Jin
- Yun-Hua Liu
- Yang Chen
- Bin-Fei Dang
- Li-Hong He
- Qi Zhang
Institutions
- Zhejiang Cancer Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1136/gutjnl-2025-336323
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00