Colchicine prophylaxis efficacy in PFAPA syndrome: A comparative cohort study
Colchicine prophylaxis significantly reduces PFAPA attack frequency, with therapeutic benefits that are independent of FMF genetic status. These findings support colchicine as an effective first-line prophylactic treatment for PFAPA patients with frequent episodes or families concerned about frequent steroid use, representing a paradigm shift from reactive to preventive management.
Authors
- Rim Kasem Ali Sliman (ORCID: https://orcid.org/0000-0001-6269-9978)
- Stav Regev
- Mohamad Hamad Saied
- Basel Ghanim
Institutions
- Technion – Israel Institute of Technology (IL)
- Carmel Medical Center (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Seminars in Arthritis and Rheumatism
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.semarthrit.2026.152941
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 22.24