Pharmacokinetic/pharmacodynamic integration of linezolid alone and in combination with fosfomycin against methicillin-resistant Staphylococcus aureus in a neutropenic murine thigh infection model
Combined linezolid and fosfomycin therapy enhances in vivo anti-MRSA efficacy, reduces the risk of resistance emergence, and lowers the exposure requirements for linezolid.
Authors
- Qin Ai
- Lu Lai
- Zaixing Chen
- Yanyan Liu
- Chunhua Peng
- Xiaohui Huang
- Fangrui Liang
- Shuai Zheng
- Sailan Wang
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.jgar.2026.01.016
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00