Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
HJEs represent a robust human-derived model to investigate EEC function and GLP-1 secretion in metabolic diseases. While HJEs retain functional GLP-1-producing cells, their secretory capacity is impaired in the presence of T2D, confirming functional endocrine alterations. These findings support the use of HJEs in preclinical studies targeting enteroendocrine dysfunction.
Authors
- Céline Osinski (ORCID: https://orcid.org/0000-0003-4897-8510)
- Dounia Moret
- Patricia Serradas (ORCID: https://orcid.org/0000-0002-6652-9746)
- Paula Martínez-Oca (ORCID: https://orcid.org/0000-0003-0377-1401)
- Agnès Ribeiro
- Hédi Antoine Soula
- Laurent Genser
- Karine Clément
- Christine Poitou
Institutions
- Inserm (FR)
- Institut Pasteur (FR)
- Sorbonne Université (FR)
- Nutrition et obésité : approches systémiques (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1038/s41366-026-02024-3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Foundation for the Study of Diabetes
- Institut National de la Santé et de la Recherche Médicale
- Assistance publique-Hôpitaux de Paris
- Sorbonne Université