Angioedema following Thrombolysis in Acute Ischemic Stroke: A Population-Based Cross-Sectional Study of 99,935 Patients

Although angioedema increased the likelihood of tracheostomy and prolonged hospitalization, outcomes were comparable to those of patients without this complication. These findings are hypothesis-generating and may help guide discussions with families when angioedema occurs, demonstrating that while the need for airway intervention is more likely, the overall prognosis remains reassuring. Future studies should further clarify acute management strategies and long-term outcomes in this patient population.

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Publication Details

Journal
Cerebrovascular Diseases
Published
2026-02-09
DOI
https://doi.org/10.1159/000549685
Primary Topic
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Type
article
Field-Weighted Citation Impact
0.00
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article

Angioedema following Thrombolysis in Acute Ischemic Stroke: A Population-Based Cross-Sectional Study of 99,935 Patients

Eris Spirollari, Brittany Russo, Anaz Uddin, Shoaib A. Syed et al.
Cerebrovascular Diseases
Coagulation, Bradykinin, Polyphosphates, and Angioedema
article

Angioedema following Thrombolysis in Acute Ischemic Stroke: A Population-Based Cross-Sectional Study of 99,935 Patients

Eris Spirollari, Brittany Russo, Anaz Uddin, Shoaib A. Syed, Mill Etienne, Ariel Sacknovitz, Sima Vazquez, Chaitanya Medicherla, Gular Mammadli, Terry Nguyen, Charanpreet Sasan, Ankita Jain, Ellen N. Huhulea, Aiden K. Lui, Dennis Paul, Kevin Clare, Fawaz Al-Mufti
article en

Abstract

Although angioedema increased the likelihood of tracheostomy and prolonged hospitalization, outcomes were comparable to those of patients without this complication. These findings are hypothesis-generating and may help guide discussions with families when angioedema occurs, demonstrating that while the need for airway intervention is more likely, the overall prognosis remains reassuring. Future studies should further clarify acute management strategies and long-term outcomes in this patient population.

Cerebrovascular Diseases
Good Samaritan Hospital (US), Westchester Medical Center (US), New York Medical College (US)
No poverty
Openalex Percentile: Top 62%
Coagulation, Bradykinin, Polyphosphates, and Angioedema
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