Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity

A novel mechanism of neutrophil reprogramming, utilizing an AAC that initiates antigen presentation in the absence of conventional cDCs, offers a translational strategy to overcome immune exclusion in solid tumors.

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Publication Details

Journal
Cancer Research Communications
Published
2026-02-09
DOI
https://doi.org/10.1158/2767-9764.crc-25-0509
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity

Kanupriya Kusumakar, Yoshimasa Ito, H. F. Wang, Qi Meng et al.
Cancer Research Communications
Immune cells in cancer
article

Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity

Kanupriya Kusumakar, Yoshimasa Ito, H. F. Wang, Qi Meng, Tanya Mayadas
article en

Abstract

A novel mechanism of neutrophil reprogramming, utilizing an AAC that initiates antigen presentation in the absence of conventional cDCs, offers a translational strategy to overcome immune exclusion in solid tumors.

Cancer Research CommunicationsVol. 6(3)
Brigham and Women's Hospital (US)
Openalex Percentile: Top 61%
Immune cells in cancer
DOIOpen Access PDFOpenAlex
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Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity — Kanupriya Kusumakar, Yoshimasa Ito, et al. · Cancer Research Communications (2026) | TGRS Research Map | TGRS