Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation in MASLD
TFEB induction promotes KC fitness upon lipid stress during MASLD. Preservation of lipid-adapted KCs demonstrates beneficial effects against liver steatosis and protects portal filtration during MASLD.
Authors
- Kathleen Byrnes (ORCID: https://orcid.org/0000-0002-9361-1120)
- Zhen Guo
- M. Fedorova
- Wandy L. Beatty (ORCID: https://orcid.org/0000-0003-0715-7361)
- Brian Finck
- Mandy M. Chan (ORCID: https://orcid.org/0000-0001-6511-0962)
- Sabine Daemen (ORCID: https://orcid.org/0000-0002-2811-8145)
- Christina Fu (ORCID: https://orcid.org/0000-0001-5555-3874)
- J. S. Schilling
- Kira Florczak
- Natalie Feldstein
- Babak Razani
- Ali Javaheri
- Christopher Park
- Arick C. Park
- Daniel Ferguson
- Li He
- Kevin Cho
- Bin Q. Yang
Institutions
- Harvard University (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Maastricht University (NL)
- Massachusetts General Hospital (US)
- UPMC Health System (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1097/hc9.0000000000000853
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00