Stress endurance mediates the healthspan-promoting effect of two newly described iridoid glycosides from Verbascum nigrum ssp. abietinum in Caenorhabditis elegans
This study provides the first evidence that iridoid glycosides 1 and 2 from V. nigrum ssp. abietinum promote C. elegans healthspan by enhancing stress response through modulation of genes related to autophagy and inflammation.
Authors
- Monika N. Todorova (ORCID: https://orcid.org/0009-0000-2892-7420)
- Milena Popova (ORCID: https://orcid.org/0000-0002-9296-9059)
- Kalina Alipieva (ORCID: https://orcid.org/0000-0003-2395-5339)
- Martina S. Savova (ORCID: https://orcid.org/0000-0002-3852-8658)
- Slaveya Krustanova
- V. V. GERASIMOVA (ORCID: https://orcid.org/0000-0002-4625-9574)
- Milen I. Georgiev
- Stoyan Stoyanov
Institutions
- Bulgarian Academy of Sciences (BG)
- Center of Plant Systems Biology and Biotechnology (BG)
- Institute of Organic Chemistry with Centre of Phytochemistry (BG)
- Institute of Biodiversity and Ecosystem Research (BG)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.phymed.2026.157944
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00