Effect of probiotic lozenges on improvement in tympanometric classification within 12 weeks in children aged 3–6 years with adenoid hypertrophy and otitis media with effusion undergoing non-surgical management: a randomized controlled trial
Daily SSK12 lozenges for 12 weeks significantly improved tympanogram classification and auditory function, mediated by enhanced probiotic colonization and pathogen suppression, with excellent safety and adherence. SSK12 represents a low-risk, biologically rational adjunct in the conservative management of pediatric OME associated with adenoid hypertrophy.
Authors
- Jun Shi (ORCID: https://orcid.org/0000-0002-6911-6381)
- He Chen (ORCID: https://orcid.org/0000-0002-4713-6904)
- Yu Liu (ORCID: https://orcid.org/0000-0002-8558-7300)
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Luomeng Chen
- Xiaofei Hou
- Xiaoning Chen
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1736602
- Primary Topic
- Ear Surgery and Otitis Media
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- State Administration of Traditional Chinese Medicine of the People's Republic of China