Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer
Overall, our work has uncovered the diverse gene features and varied anti-HBV activities of plasmablast-derived mAbs, providing a series of antibody drug candidates and the long-sought-after atomic model of AGL has paved the way for a wholistic characterisation of the AGL's dynamic conformation during HBV infection and immune response.
Authors
- Jing Gan (ORCID: https://orcid.org/0000-0001-5255-6324)
- Zhu Si (ORCID: https://orcid.org/0000-0002-6367-6556)
- Yuxiao Li
- M. X. Luo (ORCID: https://orcid.org/0000-0002-3034-3034)
- Maofu Liao
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Juanjuan Zhao (ORCID: https://orcid.org/0000-0003-1002-9272)
- Bin Zhou (ORCID: https://orcid.org/0000-0003-4245-0694)
- Qing Fan (ORCID: https://orcid.org/0000-0002-9673-5575)
- Hu Yan
- Xin Wang
- Lu Zhang
- Zheng Zhang
- Xiangyang Ge
- Bin Ju
- Wenlong Lai
- Miao Wang
- Yuchen Xia (ORCID: https://orcid.org/0000-0001-8460-3893)
- Yong Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- Shenzhen Weiguang Biological Products (China) (CN)
- Wuhan Institute of Virology (CN)
- Shenzhen Institute for Drug Control (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1136/gutjnl-2025-336641
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00