Post‐authorization safety study to assess the risk of diabetic ketoacidosis among type 2 diabetes mellitus patients treated with ertugliflozin compared to patients treated with other antihyperglycaemic agents in a Medicare and Medicaid population
Ertugliflozin was associated with a higher risk of DKA relative to comparators. HRs were higher among new users with no-concomitant insulin use than those with concomitant insulin use. Results were consistent with prior SGLT2i data and highlighted the importance of caution by both patients and physicians.
Authors
- Ashish Rai (ORCID: https://orcid.org/0000-0001-7131-7580)
- Anna Agan
- Meg Her
- Brandon J. Diessner (ORCID: https://orcid.org/0000-0002-3725-3410)
- Robert Frederich (ORCID: https://orcid.org/0000-0002-5175-3112)
- Urszula Masiukiewicz
- R. Ravi Shankar (ORCID: https://orcid.org/0000-0002-3709-0965)
- Margaret B Nolan (ORCID: https://orcid.org/0000-0001-5214-3992)
- Alecia Clary (ORCID: https://orcid.org/0000-0002-7774-9808)
- Andrea DeVries (ORCID: https://orcid.org/0000-0003-3656-8979)
- X. Peter Zhang (ORCID: https://orcid.org/0000-0001-7574-8409)
- Kimberly Daniels (ORCID: https://orcid.org/0000-0003-1862-5634)
- Ira Gantz
- James Marshall
- Sengwee Toh
- Tongtong Wang (ORCID: https://orcid.org/0009-0002-0408-7556)
- Sampada Nandyala
- Djeneba Audrey Djibo
- Melissa MacCoy Zale
- Ting‐Ying Huang
- Precious Ejelonu
- Carla Rodriguez‐Watson
Institutions
- University of Kentucky HealthCare (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Harvard University (US)
- Pfizer (United States) (US)
- Wilmington University (US)
- New England College of Optometry (US)
- Durham Technical Community College (US)
- Reagan-Udall Foundation (US)
- Harvard Pilgrim Health Care (US)
- HealthPartners (US)
- Montgomery County Community College (US)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1111/dme.70208
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00