Generative AI as an Enabler for Process Intensification

The advancement and fusion of the value chain, the industrial Internet of Things, big data with advanced analytics, and cloud computing have propelled the adoption of artificial intelligence (AI) in the design and evaluation of Process Intensification (PI), producing better results. Generative AI (GenAI) is an approach capable of generating new content with the proper database. The role of GenAI in the design of PI systems under the vision of Industry 4.0 (PI4.0) was explored. This study identified three primary categories of enablers critical to improving physical performance, digital capabilities, and strategic integration within PI4.0 systems. A brief review identified the potential of different GenAI models in PI4.0; however, through an in-depth case study (distillation column design), the GenAI application in the design of PI4.0 was shown to enable the creation of additional data and scenarios, foster increased creativity and exploration, introduce novel configurations and designs, and accelerate the pace of innovation. The results of the case study highlight the limitations of discriminative AI models and underscore the transformative potential of GenAI approaches. The most significant advantage of GenAI is its ability to expand the range of possibilities, making the PI4.0 design faster, more adaptable, innovative, and robust.

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Publication Details

Journal
Industrial & Engineering Chemistry Research
Published
2026-02-09
DOI
https://doi.org/10.1021/acs.iecr.5c04127
Primary Topic
Process Optimization and Integration
Type
article
Field-Weighted Citation Impact
0.00
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article

Generative AI as an Enabler for Process Intensification

Karla M. Esquivel-Ortiz, Antonio Flores‐Tlacuahuac, R. Morales-Menendez, Alejandro Montesinos-Castellanos et al.
Industrial & Engineering Chemistry Research
Process Optimization and Integration
article

Generative AI as an Enabler for Process Intensification

Karla M. Esquivel-Ortiz, Antonio Flores‐Tlacuahuac, R. Morales-Menendez, Alejandro Montesinos-Castellanos, Enrique A. López Guajardo
article en

Abstract

The advancement and fusion of the value chain, the industrial Internet of Things, big data with advanced analytics, and cloud computing have propelled the adoption of artificial intelligence (AI) in the design and evaluation of Process Intensification (PI), producing better results. Generative AI (GenAI) is an approach capable of generating new content with the proper database. The role of GenAI in the design of PI systems under the vision of Industry 4.0 (PI4.0) was explored. This study identified three primary categories of enablers critical to improving physical performance, digital capabilities, and strategic integration within PI4.0 systems. A brief review identified the potential of different GenAI models in PI4.0; however, through an in-depth case study (distillation column design), the GenAI application in the design of PI4.0 was shown to enable the creation of additional data and scenarios, foster increased creativity and exploration, introduce novel configurations and designs, and accelerate the pace of innovation. The results of the case study highlight the limitations of discriminative AI models and underscore the transformative potential of GenAI approaches. The most significant advantage of GenAI is its ability to expand the range of possibilities, making the PI4.0 design faster, more adaptable, innovative, and robust.

Industrial & Engineering Chemistry ResearchVol. 65(6)
Tecnológico de Monterrey (MX)
Openalex Percentile: Top 62%
Process Optimization and Integration
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