Synthesis of Novel USP1 Inhibitors and Their Uses in Treatment of USP1 Related Diseases
Ubiquitin-specific protease 1 (USP1) is a member of the deubiquitinating enzyme family that modulates the stability and biological activity of target proteins through the removal of ubiquitin modifications, thereby contributing to tumor development and resistance to anticancer therapies. This patent summary focuses on the design and optimization of a class of small-molecule inhibitors that exhibit high potency and selectivity toward USP1.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Haofeng Shi
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00031
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00