Minnelide ameliorates Col4a5+/− mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress
Minnelide demonstrates potent renoprotective effects in AS by upregulating Col4a5 expression and mitigating podocyte ER stress, positioning it as a novel therapeutic candidate.
Authors
- Jingjia Zhang (ORCID: https://orcid.org/0000-0002-8285-950X)
- Baowei Ji (ORCID: https://orcid.org/0000-0002-8530-0787)
- Ye Yin
- Jun-chao Liu
- Fu-jie Wen
- Hong Xu
- Xue Wang
- Qian Shen
- Jian Yu
Institutions
- Kidney Research UK (GB)
- Institut thématique Génétique, génomique et bioinformatique (FR)
- Children's Hospital of Fudan University (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fphar.2026.1761502
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China