Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model

This is the first study to demonstrate the efficacy of unmodified curcumin combined with FUS in a 6-OHDA PD model. The findings support FUS as a safe and effective strategy to transiently disrupt the BBB and enhance the central nervous system delivery of small-molecule therapeutic agents, offering translational potential for regionally targeted, non-invasive treatment of PD.

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Publication Details

Journal
Frontiers in Aging Neuroscience
Published
2026-02-09
DOI
https://doi.org/10.3389/fnagi.2026.1740256
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model

Chueh-Hung Wu, Chen‐Yu Hung, Ming‐Yen Hsiao, Shu-Mei Yang et al.
Frontiers in Aging Neuroscience
Ultrasound and Hyperthermia Applications
article

Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model

Chueh-Hung Wu, Chen‐Yu Hung, Ming‐Yen Hsiao, Shu-Mei Yang, Sung-Jan Lin, Sen-Hi Yeoh, Meng-Ting Lin
article en

Abstract

This is the first study to demonstrate the efficacy of unmodified curcumin combined with FUS in a 6-OHDA PD model. The findings support FUS as a safe and effective strategy to transiently disrupt the BBB and enhance the central nervous system delivery of small-molecule therapeutic agents, offering translational potential for regionally targeted, non-invasive treatment of PD.

Frontiers in Aging NeuroscienceVol. 18
National Taiwan University (TW), National Taiwan University Hospital (TW)
National Taiwan University Hospital, National Taiwan University, National Science and Technology Council
Openalex Percentile: Top 63%
Ultrasound and Hyperthermia Applications
DOIOpen Access PDFOpenAlex
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Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson’s disease mouse model — Chueh-Hung Wu, Chen‐Yu Hung, et al. · Frontiers in Aging Neuroscience (2026) | TGRS Research Map | TGRS