Association between body mass index, plasma N-terminal pro-B-type natriuretic peptide, symptoms and outcome in patients referred for investigation of suspected heart failure

In ambulatory patients with suspected HF, higher BMI is associated with lower NT-proBNP concentrations but does not attenuate the prognostic value of NT-proBNP. Lowering guideline-recommended NT-proBNP thresholds for obese patients is unlikely to identify individuals at higher mortality risk.

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Publication Details

Journal
Heart
Published
2026-02-09
DOI
https://doi.org/10.1136/heartjnl-2025-327093
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
0.00
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article

Association between body mass index, plasma N-terminal pro-B-type natriuretic peptide, symptoms and outcome in patients referred for investigation of suspected heart failure

Elton Luo, AL Clark, J G F Cleland, P Pellicori et al.
Heart
Cardiovascular Function and Risk Factors
article

Association between body mass index, plasma N-terminal pro-B-type natriuretic peptide, symptoms and outcome in patients referred for investigation of suspected heart failure

Elton Luo, AL Clark, J G F Cleland, P Pellicori, J J Cuthbert, Alan S Rigby, Syed Kazmi
article en

Abstract

In ambulatory patients with suspected HF, higher BMI is associated with lower NT-proBNP concentrations but does not attenuate the prognostic value of NT-proBNP. Lowering guideline-recommended NT-proBNP thresholds for obese patients is unlikely to identify individuals at higher mortality risk.

Heart
University of Hull (GB), Hull York Medical School (GB), University of Glasgow (GB)
Good health and well-being
Openalex Percentile: Top 63%
Cardiovascular Function and Risk Factors
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