NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate are intended to serve as a resource for health care providers to identify individuals who may benefit from cancer risk assessment and genetic counseling and testing; help guide decisions related to genetic testing; and facilitate a multidisciplinary approach in the comprehensive care of individuals at increased risk for hereditary breast, ovarian, pancreatic, and prostate cancer. The current guidelines focus primarily on assessment of pathogenic and likely pathogenic (P/LP) variants associated with increased risk of breast, ovarian, pancreatic, and prostate cancer and recommended approaches to genetic counseling/testing and care strategies in individuals with these P/LP variants associated with increased risk of these cancers. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding screening for prostate cancer and pancreas cancer, as well as testing criteria for nonepithelial ovarian cancer.
Authors
- Matthew B.B. Yurgelun (ORCID: https://orcid.org/0000-0002-6184-9273)
- Marie Wood (ORCID: https://orcid.org/0000-0002-6053-7200)
- Mary Dwyer
- Dominique Rash
- Jennifer Kay Plichta (ORCID: https://orcid.org/0000-0002-7411-0558)
- Julie S Mak
- S Friedman
- Leigha Senter-Jamieson
- Nawal Kassem (ORCID: https://orcid.org/0000-0002-4582-9600)
- Sofia Diana Merajver (ORCID: https://orcid.org/0000-0002-6823-7130)
- Myra Wick (ORCID: https://orcid.org/0000-0003-4126-4523)
- Seema A. Khan (ORCID: https://orcid.org/0000-0002-6307-2023)
- Veda N. Giri (ORCID: https://orcid.org/0000-0002-7268-5913)
- Mollie L. Hutton
- Ashley Hendrix
- Zeenat Diwan
- K. McWeeney Shannon
- MB Daly
- Jeanna Welborn
- Kara N. Maxwell
- Sarah Colonna
- Dezheng Huo
- Tuya Pal
- Susan M. Domchek
- Jacqueline Mersch
- Barbara S. Norquist
- Zahraa AlHilli
- Michael Goggins
- Mauricio R. Escobar
- Beth Y. Karlan
- Christine Laronga
- Susan Darlow
- Allison W. Kurian
- Kenneth Offit
- Kevin McDonnell
- Gwen Reiser
- Banu Arun
- Andrea Hagemann
- Heather H. Cheng
- Jane Churpek
- Laura Fejerman
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Facing Our Risk of Cancer Empowered (US)
- Dana-Farber Brigham Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2026-02-01
- DOI
- https://doi.org/10.6004/jnccn.2026.0007
- Citations
- 2
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 61.86