Pharmacokinetics and nephrotoxicity of cisplatin modulated by combination therapy with brusatol
Brusatol increases renal cisplatin concentrations by altering its pharmacokinetics, intensifying dose-dependent nephrotoxicity. Further development as a chemotherapy sensitizer requires understanding the mechanisms of this effect and optimizing the combined dose.
Authors
- Nan Guo (ORCID: https://orcid.org/0000-0001-8580-7783)
- Xiaoran Zhang (ORCID: https://orcid.org/0000-0003-0979-7100)
- Ya Zhang (ORCID: https://orcid.org/0000-0003-0894-4922)
- Q I N G Wen
- Wen Zhang
- Guiyan Yuan
Institutions
- Jinan Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fphar.2026.1708101
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00