Identification of key hubs and aberrant connectivity patterns in depression associated with white matter hyperintensity

The study identifies a triple-network (DMN-SN-CEN) functional connectivity signature in WMH-related depression, suggesting potential neuroimaging biomarkers for clinical diagnosis. The identified STG abnormalities, manifesting as concurrent structural-functional deficits, may constitute the neural substrate linking cerebrovascular pathology to depressive symptomatology. These overlapping alterations provide a promising therapeutic target for early intervention strategies.