Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis
The findings indicate that melatonin alleviates sepsis-induced myocardial injury by inhibiting ferroptosis through regulation of the sirtuin 1/nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 pathway, providing evidence supporting the potential use of melatonin in the treatment of sepsis-related myocardial injury.
Authors
- Min Zeng (ORCID: https://orcid.org/0000-0002-8843-334X)
- Lin Li
- Yi-Jun Wang
- Qiong Li
- Cheng-Fang Xiang
Institutions
- Jinan University (CN)
- Chenzhou First People's Hospital (CN)
Publication Details
- Journal
- World Journal of Cardiology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.4330/wjc.v18.i2.113358
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00