A tumor DNA-Methylome derived signature of Hypoxia Identifies HPV-negative head and neck cancer patients at risk for distant metastasis after postoperative radiochemotherapy (PORT-C)
The prognostic utility of Hypoxia-M was validated in an independent cohort. Our results highlighted a difference in recurrence patterns of hypoxic tumors treated in the primary setting (local recurrence) versus postoperatively (distant metastasis) and the utility of Hypoxia-M for identifying the main pattern of recurrence.
Authors
- Christian Schwager (ORCID: https://orcid.org/0000-0003-4945-0347)
- Jakob Liermann (ORCID: https://orcid.org/0000-0002-1445-1940)
- Katrin Rein (ORCID: https://orcid.org/0009-0007-2467-4420)
- Fabian Lohaus (ORCID: https://orcid.org/0000-0003-4043-7066)
- Ute Wirkner (ORCID: https://orcid.org/0009-0006-3330-7633)
- Ingeborg Tinhofer (ORCID: https://orcid.org/0000-0002-0512-549X)
- Maximilian Fleischmann
- Henning Schäfer (ORCID: https://orcid.org/0000-0002-5948-5095)
- Bouchra Tawk (ORCID: https://orcid.org/0000-0002-7006-2026)
- Martin Stuschke (ORCID: https://orcid.org/0000-0001-6836-0940)
- Amir Abdollahi (ORCID: https://orcid.org/0000-0002-8016-5897)
- Claus Rödel
- Daniel Zips
- Anca Ligia Grosu
- Steffen Löck
- Juliane Hoerner-Rieber
- Peter Schirmacher
- Jürgen Debus
- Mechthild Krause
- Thomas Held
- Claus Belka
- Gordana Halec
- Panagiotis Balermpas
- Stephanie E Combs
- Albrecht Stenzinger
- Christel Herold-Mende
- Annett Linge
- Fabian Weykamp
- Ina Kurth
- Maximillian Knoll
- Michael Baumann
Institutions
- Goethe University Frankfurt (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- German Cancer Society (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Frankfurt (DE)
- University Hospital Carl Gustav Carus (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.radonc.2026.111433
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Krebsforschungszentrum
- Deutschen Konsortium für Translationale Krebsforschung