Integrative multi-omics analysis of macrophage polarization-related genes in atherosclerosis development
This study integrates SMR with transcriptomic validation to reveal causal links between macrophage polarization-related genes and atherosclerosis. Key genes DNMT3A, DLGAP5, and SIRT6 were identified as significant candidate regulatory factors. Tissue-specific validation and GEO-based transcriptome analysis provided robust evidence supporting these findings, highlighting the importance of macrophage polarization in atherosclerosis pathogenesis and offering new insights for therapeutic intervention.
Authors
- Jinying Gao (ORCID: https://orcid.org/0000-0001-7805-7865)
- Yibing Zhang
- Peng Huang
Institutions
- Open University of China (CN)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13148-026-02072-6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00