Transgenic high expression of EphB4 in canine periodontal ligament stem cells modulates osteogenic differentiation and migration in cPDLSCs
These findings collectively indicate that EphB4 overexpression potentiates the osteogenic and migratory properties of cPDLSCs, thereby promoting alveolar bone repair in vivo. Our results highlight the therapeutic potential of EphB4 for periodontal and bone regeneration applications.
Authors
- Meng Zhou (ORCID: https://orcid.org/0000-0003-2688-0889)
- Yan Feng (ORCID: https://orcid.org/0000-0001-6890-7053)
- Chang Shun Li
- Shao Yue Zhu
- H H Liu
- Ni Na Xie
- Lei Wang
- Xin Zhang
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s12938-026-01533-6
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00