Distinct cytokine-producing dendritic cell profiles in females and males with major depressive disorder
These findings demonstrate sex-specific alterations in cytokine-producing DCs in MDD and a strong association between IL-23<sup>+</sup> cDCs and depressive symptom severity, suggesting a key role for these cells in immune dysregulation, particularly in females with depression.
Authors
- Judith Alferink (ORCID: https://orcid.org/0000-0002-3251-6584)
- Jana Freff
- Stefanie Scheu (ORCID: https://orcid.org/0000-0002-9707-8191)
- Kathrin Schwarte
- Anna-Lena Boller
- Bernhard T. Baune
- Maximilian Bast
- Udo Dannlowski
Institutions
- The University of Melbourne (AU)
- University of Münster (DE)
- Florey Institute of Neuroscience and Mental Health (AU)
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- Bethel University (US)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fncel.2026.1753241
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer Forschung Initiative
- Deutsche Forschungsgemeinschaft
- Westfälische Wilhelms-Universität Münster