Incorporating an NCCN-Based Systemic Therapy CNS Activity Score Into SRS Decision-Making for Patients With 5 or More Brain Metastases
Lesion number did not influence OS in patients with ≥5 BMs. Good performance status, receipt of CNS-active systemic therapy after SRS, and stable systemic disease predicted improved OS and WBRT-FS. Our publicly available online nomogram can inform patient-specific treatment decisions for individuals with ≥5 BMs (https://medcalc.mdanderson.org/WbrtCalc).
Authors
- S. Mcgovern
- Melisa Pasli (ORCID: https://orcid.org/0000-0001-9881-8713)
- Dennis Mackin (ORCID: https://orcid.org/0000-0002-2557-5340)
- Stephanie O. Dudzinski (ORCID: https://orcid.org/0000-0001-9222-472X)
- Christina Abi Faraj (ORCID: https://orcid.org/0000-0002-6441-4291)
- Amol J. Ghia (ORCID: https://orcid.org/0000-0002-6965-4577)
- Subha Perni
- Betty YS Kim
- Martin C. Tom (ORCID: https://orcid.org/0000-0002-2757-8641)
- Thomas Hendrix Beckham (ORCID: https://orcid.org/0000-0001-6189-6996)
- Tina M. Briere (ORCID: https://orcid.org/0000-0001-5829-3991)
- Isabella Claudia Glitza
- Diana Kaya (ORCID: https://orcid.org/0000-0002-6494-855X)
- Ecaterina E Ileana Dumbrava (ORCID: https://orcid.org/0000-0002-1959-0536)
- Xiuning Le
- D. Massi
- Mary Frances McAleer
- Caroline Chung
- Wen Jiang
- Sherise D. Ferguson
- Jing Li
- Michael K. Rooney
- Chenyang Wang
- Todd Swanson
- D. Nana Yeboa
- Brian De
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Blakelands Hospital (GB)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2026-02-01
- DOI
- https://doi.org/10.6004/jnccn.2025.7103
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00