A Teaching–Learning Sequence Integrating Nature of Science and Scientific Inquiry: Design Implementation and the Role of Historical Experiments

This study investigates the development and impact of a teaching–learning sequence (TLS) designed for biology students with the aim of enhancing their understanding of key aspects of the nature of science (NOS) and the nature of scientific inquiry (NOSI). The TLS was developed within a design-based research (DBR) framework and centers on Griffith’s pivotal historical experiment to provide contextual depth and integrate both epistemic and non-epistemic dimensions of science. Instruction was based on explicit and reflective inquiry involving progressive scaffolding of students from structured towards more open investigative activities. An initial implementation with nine students, drawing on data from questionnaires and interviews, revealed their prior views regarding several NOS and NOSI aspects. Following the TLS, students demonstrated a more sophisticated understanding of the role of research questions in guiding experimental design, as well as a richer conception of scientific hypotheses. They also internalized the experimental logic underlying Griffith’s work and recognized the importance of creativity and imagination in scientific practice. The study discusses contextual limitations and highlights the potential of TLSs to provide robust instructional contexts, making NOS and NOSI aspects meaningful and accessible to students through historical experiments.