Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance
These findings suggest that TNBC chemoresistance is linked to the 3-MST/H2S pathway. Pharmacological inhibition of 3-MST by HMPSNE enhances the chemotherapeutic effect of doxorubicin on TNBC. Some of these effects may be related to the regulation of CD44 but are unlikely to be mediated via the PI3K/AKT/mTOR pathway. Therefore, pharmacological inhibition of 3-MST may serve as a promising target for further investigations to increase the sensitivity of TNBC cells to doxorubicin-based therapies.
Authors
- D.A. Habashy (ORCID: https://orcid.org/0000-0003-3890-6820)
- Carole Bourquin (ORCID: https://orcid.org/0000-0003-3862-4583)
- Rana A. Youness
- Kelly Ascenção (ORCID: https://orcid.org/0000-0001-6693-6897)
- Reham M. M. Abdelkader
- Sousanna Hakim
- Csaba Szabo
- Mohamed Z. Gad
Institutions
- University of Bern (CH)
- University of Fribourg (CH)
- Ono Pharmaceutical (United States) (US)
- Institute of Molecular Biology and Biotechnology (BG)
- Institute of Pharmacology (CZ)
- German University in Cairo (EG)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fphar.2026.1748950
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00