Acute Ischemic Stroke as the Initial Manifestation of Antiphospholipid Syndrome After SARS-CoV-2 Infection in a 17-Year-Old Patient

Stroke is an unusual condition in young adults, but when it presents in this population, there are specific causes that differ from those in older adults. When this occurs, it is necessary to make an extensive assessment to establish a final diagnosis. One of these causes, as in the case presented, is antiphospholipid syndrome (APS), which can present as venous or arterial thrombosis. There are conditions that act as triggers for the formation of antiphospholipid antibodies (aPL) and the development of APS. This report illustrates these points by presenting a young patient who developed APS after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that acted as a trigger, along with probable genetic susceptibility factors, and was diagnosed in accordance with guidelines 12 weeks after initial presentation. He was successfully treated with rescue mechanical thrombolysis, with favorable outcomes.

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Publication Details

Journal
Cureus
Published
2026-02-09
DOI
https://doi.org/10.7759/cureus.103286
Primary Topic
Heparin-Induced Thrombocytopenia and Thrombosis
Type
article
Field-Weighted Citation Impact
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article

Acute Ischemic Stroke as the Initial Manifestation of Antiphospholipid Syndrome After SARS-CoV-2 Infection in a 17-Year-Old Patient

Alberto Cervantes-Hernández, Mauricio E. Rodríguez Vergara, Daniel E Córdova Galván, Carlos A Gómez Núñez et al.
Cureus
Heparin-Induced Thrombocytopenia and Thrombosis
article

Acute Ischemic Stroke as the Initial Manifestation of Antiphospholipid Syndrome After SARS-CoV-2 Infection in a 17-Year-Old Patient

Alberto Cervantes-Hernández, Mauricio E. Rodríguez Vergara, Daniel E Córdova Galván, Carlos A Gómez Núñez, Carlos A Portales Cameras
article en

Abstract

Stroke is an unusual condition in young adults, but when it presents in this population, there are specific causes that differ from those in older adults. When this occurs, it is necessary to make an extensive assessment to establish a final diagnosis. One of these causes, as in the case presented, is antiphospholipid syndrome (APS), which can present as venous or arterial thrombosis. There are conditions that act as triggers for the formation of antiphospholipid antibodies (aPL) and the development of APS. This report illustrates these points by presenting a young patient who developed APS after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that acted as a trigger, along with probable genetic susceptibility factors, and was diagnosed in accordance with guidelines 12 weeks after initial presentation. He was successfully treated with rescue mechanical thrombolysis, with favorable outcomes.

CureusVol. 18(2)
Universidad La Salle (BO), Hospital Angeles Pedregal (MX), Universidad Mexicana (MX)
Good health and well-being
Openalex Percentile: Top 62%
Heparin-Induced Thrombocytopenia and Thrombosis
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