Interpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example

These findings demonstrate that HQQFD ameliorates LPS-induced ALI in rats by regulating the inflammatory response. The combination of WSR and GFP at high dose shows the best therapeutic effect, and the 20 identified compounds are potential pharmacodynamic substances of HQQFD. This study provides experimental evidence for the clinical optimization and quality control of HQQFD in the treatment of ALI.

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Publication Details

Journal
Chinese Medicine
Published
2026-02-09
DOI
https://doi.org/10.1186/s13020-026-01341-z
Primary Topic
Flavonoids in Medical Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Interpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example

Zhe Jia, Cun Zhang, Yun Wang, Ying Liu et al.
Chinese Medicine
Flavonoids in Medical Research
article

Interpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example

Zhe Jia, Cun Zhang, Yun Wang, Ying Liu, Lin Yan, Yanping Liu, Qing Zhang, Yanan Song
article en

Abstract

These findings demonstrate that HQQFD ameliorates LPS-induced ALI in rats by regulating the inflammatory response. The combination of WSR and GFP at high dose shows the best therapeutic effect, and the 20 identified compounds are potential pharmacodynamic substances of HQQFD. This study provides experimental evidence for the clinical optimization and quality control of HQQFD in the treatment of ALI.

Chinese MedicineVol. 21(1)
Henan University of Traditional Chinese Medicine (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Hebei Chemical and Pharmaceutical College (CN), China Academy of Chinese Medical Sciences (CN), First Affiliated Hospital of Henan University (CN)
Good health and well-being
Openalex Percentile: Top 62%
Flavonoids in Medical Research
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Interpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example — Zhe Jia, Cun Zhang, et al. · Chinese Medicine (2026) | TGRS Research Map | TGRS